ABSTRACT
We report the clinical features of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a family setting of 13 people with person-to-person transmission in Yancheng, Jiangsu Province, China.
ABSTRACT
Water is essential for a sustainable economic prosperity, but rapid economic growth and intensive agricultural activities usually cause water pollution. The middle and lower reaches of China’s Yangtze River Basin were urbanized and industrialized much earlier than the upper reach and have been suffering from water pollution. In the past two decades, economic growth accelerated in the upper reach due to several national economic initiatives. Based on analyzing water quality changes from 2000 to 2019 and during the COVID-19 lockdown in 2020 for Chengdu in the upper reach, we hope to provide some water governance suggestions. In 2019, water at 66% of 93 sites in Chengdu did not achieve the national III standards using measurements of 23 water quality parameters. The top two pollutants were total nitrogen (TN) and fecal coliform (FC). From 2000 to 2019, water quality was not significantly improved at the non-background sites of Chengdu's Min Basin, and the pollution in this basin was mainly from local pollutants release. During the same period, water quality deteriorated in Chengdu’s Tuo Basin, where pollution was the result of pollutant discharges in Chengdu in addition to inter-city pollutant transport. During the COVID-19 lockdown, water quality generally improved in the Min Basin but not in the Tuo Basin. A further investigation on which pollution sources were shut down or not during the lockdown can help make pollution reduction targets. Based on the results, we provide suggestions to strengthen inter-jurisdictional and inter-institutional cooperation, water quality monitoring and evaluation, and ecological engineering application.
ABSTRACT
Recent studies have revealed that cancer patients had a higher risk of having coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), compared to patients without cancer. The expression of angiotensin-converting enzyme 2 (ACE2), the receptor of SARS-CoV-2, was aberrantly expressed in many tumors. In this study, by exploring the TCGA and GTEx public databases, we investigated ACE2 expression and its association with prognosis in non-small cell lung cancer (NSCLC), the most susceptible caner type. We found that lung was one of the major organs with highly expressed ACE2. Furthermore, ACE2 expression was significantly elevated in lung adenocarcioma (LUAD) and lung squamous cell carcinoma (LUSC) compared to normal tissues. DNA methylation might be one possible mechanism leading to ACE2 upregulation. Despite that, the AEC2 expression was not statistically associated with disease-free survival (DFS) and overall survival (OS) for LUAD patients, and higher ACE2 expression was associated with prolonged DFS in LUSC patients. Taken together, we observed ACE2 was highly expressed in LUAD and LUSC despite the controversial role of ACE2 expression in predicting prognosis in these two common lung cancer types.
ABSTRACT
We report the clinical features of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a family setting of 13 people with person-to-person transmission in Yancheng, Jiangsu Province, China.